8:30am               Introduction to the Symposium

                                Steve Cummings

8:45am               Entropy 101

                                Alan Cohen

OVERVIEW - ENTROPY IN THE CONTEXT OF AGING

9:00am               Entropy and the biology of aging

                                Luigi Ferrucci

9:15am               Entropy, deleteriome and life

                                Vadim Gladyshev

9:30am               Dissipative entropy: rates and states

                                Steve Cummings

9:45am               Intrinsic / extrinsic entropy

                                Monty Montano

10:00am             Discussion: The roles of entropy in living and aging

                                Moderator: Monty Montano

10:30am             Break

METHODS FOR QUANTIFYING ENTROPY

10:50am             Shannon entropy

                                Paul Laurienti

11:10am              Entropy, heterogeneity, and dysregulation: DISCO and Mahalanobis distance

                                Alan Cohen

11:30am:            Covariance and polygenic risk scores

                                Nicholas Schork

11:50am              Discussion and questions about methods

12:15pm             Lunch

EXAMPLES OF ENTROPY AND AGING

1:00pm               Stochastic mechanisms of aging

                                Jan Vijg

1:20pm               Mutations and epimutations as stochastic mechanisms of aging

                                Xiao Dong

1:40pm               Entropy and DNA repair

                                Björn Schumacher

2:00pm              Transcriptional entropy

                                TBN

2:20pm               Mitochondrial entropy

                                Greg Tranah

2:40pm               Proteomic entropy and clinical outcomes

                                Tyler Mansfield

3:00pm               Entropy in metabolomics (and other?)

                                Janith Duo

3:20pm               Break

3:40pm               Entropy in cell senescence

                                TBN (Nathan LeBrasseur)

4:00pm               Dietary entropy and longevity

                                Paola Sebastiani

4:20pm               Entropy in ECGs and clinical biomarkers

                                Namki Hong

4:40pm               Entropy in muscle fibers and mobility

                                Sangwouk Cho

5:00pm               Discussion

9am                     Introduction to Day 2

                                Steve Cummings

MORE EXAMPLES OF ENTROPY IN AGING

9:10                     Entropy in brain networks and mobility

                                Paul Laurienti

9:30                     Role of entropy in development of frailty

                                TBN (Karen Bandeen-Roche)

9:50                     New research: 10 minute presentations

                                To be selected from abstract submissions in August

INTEGRATIONS ACROSS SPECIES AND WITHIN INDIVIDUALS

10:20                  Entropy across species

                                Evan Hadley

10:40                  Entropy across systems and organ-specific entropy

                                Alan Cohen

11:00                   Break

INTERVENTIONS TO SLOW AND REVERSE ENTROPY

11:20                  Slowing the accumulation of entropy

                              Steve Cummings

11:40                  Thermodynamic biological age (tBA), and age-reversal

                                Andrei Tarkhov

Entropy and rejuvenation

                                Vittorio Sebastiano

12:00                  Discussion

12:40pm            Research opportunities

                                Alan Cohen, Steve Cummings, Luigi Ferrucci

1:00pm               Adjourn