8:00am               Introduction to the Symposium

                                Steve Cummings

8:10am                Entropy 101

                                Alan Cohen

OVERVIEW - ENTROPY IN THE CONTEXT OF BIOLOGY

8:30am               What do we mean by entropy? A taxonomy for aging.

                                Andrew Rutenberg

8:50am               Entropy and the biology of aging

                                Luigi Ferrucci

9:10am                Entropy, deleteriome and life

                                Vadim Gladyshev

9:30am Discussion:

‍ ‍Panel: Luigi Ferrucci, David Meyer, Vadim Gladyshev, Alan Cohen

Moderator & provocateur: Steve Cummings

10:00am‍ Break

METHODS FOR QUANTIFYING ENTROPY

10:20am             Shannon entropy

                                Paul Laurienti

10:40am             Entropy, heterogeneity, and dysregulation: DISCO and Mahalanobis distance

                                Alan Cohen

11:00am:            Evaluating Individual and Population-Level Entropy Using Covariance Matrices

                                Nicholas J. Schork

11:20am              Questions:

Alan Cohen (Moderator), Paul Laurienti, Tyler Mansfield

11:50am      Lunch

12:40: Highlights from the Entropy in Aging meeting in Cologne ‍ ‍

David Meyer

EXAMPLES OF ENTROPY AND AGING

1:00pm               Stochastic mechanisms of aging

                                Jan Vijg

1:20pm               Mutations and epimutations as stochastic mechanisms of aging

                                Xiao Dong

1:40pm               Entropy and DNA repair

                                Björn Schumacher

2:00pm              Transcriptome entropy: Mitochondria to clinical measures

                                Greg Tranah

2:20pm               Proteomic entropy and clinical outcomes

                                Tyler Mansfield

2:40pm Entropy at Molecular and Clinical Levels

Janith Don

3:00pm               Break

3:30pm               Cellular Senescence and Entropy

                                Nathan LeBrasseur

3:50pm               Dietary entropy and longevity

                                Paola Sebastiani

4:10pm                Entropy in ECGs and clinical biomarkers

                                Namki Hong

4:30pm               Entropy in Imaging Modalities

                                Sang Wouk Cho

4:50pm               Discussion: All speakers | Moderator & provocateur: Steve Cummings

9:00am               Introduction to Day 2

                                Steve Cummings

MORE EXAMPLES OF ENTROPY AND AGING

9:10am                Entropy in brain networks and mobility

                                Paul Laurienti

INTEGRATIONS ACROSS SPECIES AND WITHIN INDIVIDUALS

9:30am               Entropy across species

                                Evan Hadley

9:50am              Entropy across systems and organ-specific entropy

                                Alan Cohen

10:10am              Break

INTERVENTIONS TO SLOW AND REVERSE ENTROPY

10:30am             Slowing the accumulation of entropy

                              Steve Cummings

10:50am             Thermodynamic biological age (tBA), and age-reversal

                                Andrei Tarkhov

11:10am Entropy and rejuvenation

                                Vittorio Sebastiano

11:30am              Discussion: Andrei Tarkhov, Vittorio Sebastiano, Björn Schumacher

Moderator & provocateur: Luigi Ferrucci

12:10pm           Research opportunities

                                Alan Cohen, Steve Cummings, Luigi Ferrucci

12:40pm              Adjourn