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8:00am Introduction to the Symposium
Steve Cummings
8:10am Entropy 101
Alan Cohen
8:30am Thermodynamic Entropy
Steve Cummings
8:50am What do we mean by entropy? A taxonomy for aging.
Andrew Rutenberg
9:10am Entropy and the biology of aging
Luigi Ferrucci
9:30am Entropy, deleteriome and life
Vadim Gladyshev
9:50am Discussion:
Panel: Luigi Ferrucci, David Meyer, Vadim Gladyshev, Alan Cohen
Moderator: Steve Cummings
10:20am Break
METHODS FOR QUANTIFYING ENTROPY
10:40am Shannon entropy
Paul Laurienti
11:00am Entropy, heterogeneity, and dysregulation: DISCO and Mahalanobis distance
Alan Cohen
11:20am: Evaluating Individual and Population-Level Entropy Using Covariance Matrices
Nicholas J. Schork
11:40am Questions:
Alan Cohen (Moderator), Paul Laurienti, Tyler Mansfield
12:00pm Lunch
12:40: Highlights from the Entropy in Aging meeting in Cologne
David Meyer
EXAMPLES OF ENTROPY AND AGING
1:00pm Stochastic mechanisms of aging
Jan Vijg
1:20pm Mutations and epimutations as stochastic mechanisms of aging
Xiao Dong
1:40pm Entropy and DNA repair
Björn Schumacher
2:00pm Mitochondria DNA and RNA
Greg Tranah
2:20pm Proteomic entropy and clinical outcomes
Tyler Mansfield
2:40pm Entropy at Molecular and Clinical Levels
Janith Don
3:00pm Break
3:30pm Cellular Senescence and Entropy
Nathan LeBrasseur
3:50pm Dietary entropy and longevity
Paola Sebastiani
4:10pm Entropy in ECGs and clinical biomarkers
Namki Hong
4:30pm Discussion: All speakers | Moderator & provocateur: Steve Cummings
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9:00am Introduction to day 2
Steve Cummings
ENTROPY IN IMAGING
9:10am Entropy in Imaging Modalities
Sangwouk Cho
9:30am Entropy in brain networks and mobility
Paul Laurienti
INTEGRATIONS ACROSS SPECIES AND WITHIN INDIVIDUALS
9:50am Entropy across species
Evan Hadley
10:10am Entropy across systems and organ-specific entropy
Alan Cohen
10:30am Break
INTERVENTIONS TO SLOW AND REVERSE ENTROPY
11:00am Thermodynamic biological age (tBA), and age-reversal
Andrei Tarkhov
11:20am Entropy and rejuvenation
Vittorio Sebastiano
11:40am Discussion: Can rejuvenation reverse entropy?
Andrei Tarkov, Vittorio Sebastiano, Björn Schumacher
Moderator & provocateur: Luigi Ferrucci
12:10pm Opportunities for collaborations
Steve Cummings
12:20pm Adjourn