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8:00am Introduction to the Symposium
Steve Cummings
8:10am Entropy 101
Alan Cohen
OVERVIEW - ENTROPY IN THE CONTEXT OF BIOLOGY
8:30am Entropy and the biology of aging
Luigi Ferrucci
8:50am Entropy, deleteriome and life
Vadim Gladyshev
9:10am Dissipative entropy: Jekyll and Hyde
Steve Cummings
9:30am Intrinsic extrinsic entropy
Monty Montano
9:50am Break
10:10am Discussion: The roles of entropy in living and aging
Panel: Luigi Ferrucci, David Meyer, Vadim Gladyshev, Alan Cohen
Moderator & provocateur: Monty Montano
METHODS FOR QUANTIFYING ENTROPY
10:40am Shannon entropy
Paul Laurienti
11:00am Entropy, heterogeneity, and dysregulation: DISCO and Mahalanobis distance
Alan Cohen
11:20am: Evaluating Individual and Population-Level Entropy Using Covariance Matrices
Nicholas J. Schork
11:40am Questions and answers about entropy
Alan Cohen (Moderator), Paul Laurienti, Tyler Mansfield
12:10pm Lunch
EXAMPLES OF ENTROPY AND AGING
1:00pm Stochastic mechanisms of aging
Jan Vijg
1:20pm Mutations and epimutations as stochastic mechanisms of aging
Xiao Dong
1:40pm Entropy and DNA repair
Björn Schumacher
2:00pm Transcriptome entropy: Mitochondria to clinical measures
Greg Tranah
2:20pm Proteomic entropy and clinical outcomes
Tyler Mansfield
2:40pm Entropy at Molecular and Clinical Levels
Janith Don
3:00pm Break
3:30pm Cellular Senescence and Entropy
Nathan LeBrasseur
3:50pm Dietary entropy and longevity
Paola Sebastiani
4:10pm Entropy in ECGs and clinical biomarkers
Namki Hong
4:30pm Entropy in Imaging Modalities
Sang Wouk Cho
4:50pm Discussion: All speakers, Moderator & provocateur: Steve Cummings
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9:00am Introduction to Day 2
Steve Cummings
MORE EXAMPLES OF ENTROPY AND AGING
9:10 Entropy in brain networks and mobility
Paul Laurienti
9:30 New research: 10 minute presentations
To be selected from abstract submissions in August
INTEGRATIONS ACROSS SPECIES AND WITHIN INDIVIDUALS
10:00 Entropy across species
Evan Hadley
10:20 Entropy across systems and organ-specific entropy
Alan Cohen
11:00 Break
INTERVENTIONS TO SLOW AND REVERSE ENTROPY
11:20 Slowing the accumulation of entropy
Steve Cummings
11:40 Thermodynamic biological age (tBA), and age-reversal
Andrei Tarkhov
12:00 Entropy and rejuvenation
Vittorio Sebastiano
12:20 Discussion: Andrei Tarkhov, Vittorio Sebastiano, Björn Schumacher
Moderator & provocateur: Luigi Ferrucci
1:00pm Research opportunities
Alan Cohen, Steve Cummings, Luigi Ferrucci
1:30pm Adjourn